SymbolBiocompatibility of new silicone intraocular lenses implanted into rabbit eyes

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The soft intraocular lenses materials mainly include silica gel, hydrophobic acrylate, hydrophilic acrylate and hydrogel. The long-term biological characteristics of these materials are unclear because of their own advantages and disadvantages. Currently, the development of new materials is a hotspot research in order to improve the biocompatibility and optical property of intraocular lenses to achieve well visual quality of patients after cataract surgery.


To evaluate the biocompatibility of self-prepared new silicone intraocular lenses (IOLs) implanted into rabbit eyes for 6 months.


Twenty New Zealand albino rabbits undergoing phacoemulsification combined with intraocular lenses implantation in the left eye were divided into two groups randomly. The experimental group was implanted with T-10 IOLs. The rabbits implanted with EFC550 IOLs were taken as control.


Serious anterior chamber exudation was observed at later stage after operation in both groups and the difference in exudation between the two groups was not significant. The degrees of the posterior capsule opacification of the rabbit eyes in the experimental and control groups had no difference. The degree of the posterior synechia in the experimental group was lower than that in the control group at 90 and 180 days. The uveal biocompatibility of T-10 IOLs is better than that of the EFC550 IOLs.T-10 IOLs have a clinical applicability.


Liu XN, Xu X, Li LL, Luo L, Nan KH, Chen H. Biocompatibility of new silicone intraocular lenses implanted into rabbit eyes. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(8): 1417-1420. [http://www.crter.cn]

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