SymbolPreparation and properties of chitosan/tricalcium phosphate composite scaffolds

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Abstract

BACKGROUND:

Composite scaffolds prepared with appropriate mixing process can make up the insufficient of single material and satisfy the needs of tissue engineering in maximum.

OBJECTIVE:

To prepare the chitosan/tricalcium phosphate composite scaffold and explore its feasibility of serving as scaffold for pulp tissue engineering.

METHODS:

Chitosan powder was dissolved in small amount of acetic acid solution. The mixture was stirred to uniform, stilled to deaeration. Then pre-cooling and cross-linking were performed. Sponge-like chitosan/tricalcium phosphate composite scaffold was prepared after anther pre-cooling and cross-linking.

RESULTS AND CONCLUSION:

Average porosity of the chitosan/tricalcium phosphate composite scaffold prepared by freeze-drying method was 85.78% and the highest porosity was over 90%. The aperture was 100-300 μm. The composite scaffold had a good toughness, and could not be damaged at over 5 mm of axial compression deformation. The cell toxicity was below grade 0 after cultured in the extracts of the materials. The chitosan/tricalcium phosphate composite scaffold can satisfy the basic needs of biomaterials based on its good biocompatibility, cell affinity, and some mechanical properties.

RESULTS AND CONCLUSION:

Yan XP, Li S, Su WX, Song J, He JM. Preparation and properties of chitosan/tricalcium phosphate composite scaffolds. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(8): 1421-1424. [http://www.crter.cnhttp://en.zglckf.com]

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