SymbolPreparation and properties of chitosan/tricalcium phosphate composite scaffolds

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Composite scaffolds prepared with appropriate mixing process can make up the insufficient of single material and satisfy the needs of tissue engineering in maximum.


To prepare the chitosan/tricalcium phosphate composite scaffold and explore its feasibility of serving as scaffold for pulp tissue engineering.


Chitosan powder was dissolved in small amount of acetic acid solution. The mixture was stirred to uniform, stilled to deaeration. Then pre-cooling and cross-linking were performed. Sponge-like chitosan/tricalcium phosphate composite scaffold was prepared after anther pre-cooling and cross-linking.


Average porosity of the chitosan/tricalcium phosphate composite scaffold prepared by freeze-drying method was 85.78% and the highest porosity was over 90%. The aperture was 100-300 μm. The composite scaffold had a good toughness, and could not be damaged at over 5 mm of axial compression deformation. The cell toxicity was below grade 0 after cultured in the extracts of the materials. The chitosan/tricalcium phosphate composite scaffold can satisfy the basic needs of biomaterials based on its good biocompatibility, cell affinity, and some mechanical properties.


Yan XP, Li S, Su WX, Song J, He JM. Preparation and properties of chitosan/tricalcium phosphate composite scaffolds. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(8): 1421-1424. [http://www.crter.cn]

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