SymbolApplications of tissue-engineered cartilage and scaffold constructed using different materials

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The development of tissue engineering technology provides a new way for cartilage regeneration and repair; according to the structure and characteristics of cartilage, the substitute materials and scaffold materials, as artificial cartilage, should have good biomechanical properties.


To summarize the application progress of repair materials and scaffold materials for exercise-induced articular cartilage injury; to summarize the biomechanical properties of biological substitute materials; to evaluate the performance and prospects of the current application of tissue-engineered cartilage materials.


A computer-based online search of VIP Database and PubMed database was performed for the articles related to the application of tissue-engineered cartilage published from January 1990 to August 2011, with the key words of “tissue engineering”, “cartilage tissue”, “scaffold material” and “biological compatibility”. Articles related to the biomaterials and tissue-engineered cartilages were included; repetitive studies and Meta analysis were excluded. The types, performance, application effects and prospects of tissue-engineered cartilage materials were mainly discussed based on 24 documents.


In the current field of cartilage repair, autologous cartilage transplantation has the best repairing effects; bone marrow stromal cells are well studied in animal experiments and in vitro tests, while their clinical applications are less reported and still in the exploratory stage. The applications of scaffold are complex; natural materials, synthetic materials and composite materials all have some deficiencies. Although the composite materials has become a hot research area, but its performance does not meet the requirement of scaffolds; and the long-term impacts caused by these materials on the body can not be seen. Therefore, there is an urgent need for new materials which can better meet the requirements of tissue-engineered cartilage scaffolds to achieve the purpose of repair and reconstruction.


Zhang X. Applications of tissue-engineered cartilage and scaffold constructed using different materials. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(8): 1491-1495. [http://www.crter.cn]

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