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Studies have shown that the classical Wnt/β-catenin signal pathway is closely related to the occurrence and development of osteoarthritis. Wnt protein family, β-catenin and related inhibitors can regulate the function and metabolism of chondrocytes.


To summarize the relationship between Wnt/β- catenin signal pathway and osteoarthritis.


A computer online search was performed to fine papers published between 2000 and 2011 in CNKI database and PubMed database. The key words of “Wnt/β-catenin, OA, osteoarthritis, cartilage cells” were used. Documents concerning the effects of Wnt/β- catenin signal pathway on osteoarthritis were included.


Currently, studies show that the Wnt/β- catenin signal pathway is one of the important way to restrain the integrity of joint and regulate the metabolism of bone joint, can influence the osteoarthritis. Wnt signal pathway and its downstream signal osteoprotegerin/receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B can regulate and control the articular cartilage metabolism result in osteoarthritis. However, the specific mechanism is still unclear. The research of components and effect of Wnt signal pathway are important for the special treatment of osteoarthritis and the prevention of osteoporosis or other diseases.

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