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Abstract

BACKGROUND:

Several studies have demonstrated that adipose-derived stem cells have tissue reparative ability, but few studies have been reported about application of adipose-derived stem cells in facial rejuvenation treatment.

OBJECTIVE:

Primary adipose-derived stem cells were isolated from human liposuction aspirates and added into adipose tissue. The compounds were injected into the face of patients who underwent face lifting through tempus incision. The aesthetic effects were observed.

METHODS:

Clinical data of 20 female patients who underwent fact lifting between June 2009 and August 2011 in Department of Plastic Surgery, General Hospital of Shenyang Military Command were retrospectively analyzed. Ten patients who received autologous adipose-derived stem cells assisted treatment were included in the treatment group, and the remaining 10 patients who underwent simple facial lifting were included in the control group. The therapeutic effects were evaluated using score of wrinkle standard and VISIA professional skin image analysis system in terms of freckle, pores, wrinkle, and skin texture.

RESULTS AND CONCLUSION:

Twenty patients were followed by 3-15 months. There was no significant difference in the score of wrinkle standard between treatment and control groups (P > 0.05). It suggests that autologous adipose-derived stem cells assisted treatment and simple face lifting have no obvious difference in reducing the wrinkles. VISIA skin detection results showed that there was a greater improvement in freckle and pores in the treatment group compared with the control group (P < 0.05) and there was no significant difference in improvement in skin texture and wrinkles (P > 0.05). These results suggest that autologous adipose-derived stem cells assisted treatment and simple face lifting have similar effects in facial rejuvenation, but the former exhibits better effects than the latter one on improving pores and freckle.

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