Different ways of bone marrow mesenchymal stem cells transplantation produce different degrees of functional recovery of spinal cord injury. Transplantation of simple bone marrow mesenchymal stem cells yields unsatisfactory efficacy in recovery of spinal cord injury.OBJECTIVE:
To review the transplantation routes and combination modes regarding bone marrow mesenchymal stem cells transplantation for the treatment of experimental spinal cord injury.METHODS:
A computer-based online retrieval was performed by the first author in CNKI and PubMed databases to search papers published during 1995-01/2011-12 with the key words “ bone marrow mesenchymal stem cells, cellular transplant, spinal cord injury, explanation channel, modality alliance” in Chinese and English. Forty-seven papers were included in the final analysis.RESULTS AND CONCLUSION:
There are many transplantation routes used for cell transplantation for the treatment of spinal cord injury, including in situ transplantation, transplantation via the cerebrospinal fluid, intravenous transplantation, transplantation via the abdominal cavity and tissue engineering scaffold. The tissue engineering scaffold method produces optimal efficacy, followed by in situ transplantation and transplantation via the cerebrospinal fluid, and the efficacy of intravenous transplantation and transplantation via the abdominal cavity is poor. Bone marrow mesenchymal stem cells combined with other ways of transplantation in the treatment of spinal cord injury has been widely recognized by scholars, but the treatment schemes of spinal cord injury targeting different injury times, patterns and extents need to be further standardized and assessed.