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Abstract

BACKGROUND:

Stem cells have the characteristics that can differentiate into chondrocytes. Stem cell transplantation for the treatment of osteoarthritis has been confirmed in a large number of animal experiments, and the clinical application is just beginning.

OBJECTIVE:

To investigate the interventional effects of traditional Chinese medicine in the treatment of osteoarthritis by stem cells transplantation.

METHODS:

The CNKI database and PubMed database (1997-01/2011-12) were used to search the articles about the effect of traditional Chinese medicine in the treatment of osteoarthritis by stem cells transplantation. The key words are “traditional Chinese medicine, osteoarthritis, stem cell and transplantation”. Then 32 articles were included for review.

RESULTS AND CONCLUSION:

With the modernization of traditional Chinese medicine, according to traditional Chinese medicine theory, studies have shown that traditional Chinese medicine application for osteoarthritis can promote the proliferation of chondrocytes, accelerate the differentiation of stem cells into chondrocytes, and facilitate the repair of cartilage defects. But the researches at the present stage are inadequate, so the basic research regarding the interventional effects of traditional Chinese medicine on stem cells should be strengthened in the future. On the basis of stem cell proliferation, differentiation and trans-differentiation mechanism, we should screen the Chinese medicine monomer or compound that can interfere the stem cells at different developmental stages.

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