Jiuxianluohanjiegu decoction composed of purslane speedwell herb, glabrous sarcandra herb, and Glomeris nipponica Kishida can promote blood circulation to clear blood stasis and remove obstruction in the collateral, rejoin bone fracture, reduce selling, and relieve pain.OBJECTIVE:
To observe the effect and mechanism of Miao Nationality's Jiuxianluohanjiegu decoction on promoting the healing of rabbit tibial fractures.METHODS:
Jiuxianluohanjiegu decoction was decocted to the required concentration using the traditional Chinese medicine method, and then filtrated using millipore filtration for standby. Right tibialis anterior disruption in New Zealand rabbits, 3 mm in width and 2 mm in depth, was performed to prepare bone defect models. Then, the models were randomly divided into three groups: Jiegu decoction group (experimental group), Sanqi (Panax Notoginseng) control group, and saline group. Body weight, body temperature, X-ray, with blood cells, red blood cells, platelets, serum calcium, serum phosphate, alkaline phosphatase concentration changes of New Zealand rabbits were observed at different phases of fracture healing.RESULTS AND CONCLUSION:
Jiuxianluohanjiegu decoction promoted callus growth, and shortened the healing time. Compared with the other two groups, weight growth were faster, serum calcium and phosphorus levels were significantly increased for 2 weeks, and serum alkaline phosphatase level was increased significantly for 21 days in the experimental group (P < 0.05). Jiuxianluohanjiegu decoction could promote calcium deposition at the fracture end, and greatly contribute to fracture healing. These findings indicate that Miao Nationality's Jiuxianluohanjiegu decoction can promote callus formation and shorten healing time in the treatment of rabbit tibial fractures.