The studies have showed that the dry and cold environment of Xinjiang area can affect many diseases, but the specific mechanism is unknown, which is not conducive to carry out the geographical and personalized treatment for the diseases.OBJECTIVE:
To reveal the effect of cold and dry environment composite different diseases predisposing factor on the expression of matrix metalloproteinase 1 mRNA in rat bone tissue.METHODS:
The models were established by smoking or dripping pancreatic elastase in trachea combined with smoking, and stimulated with cold and dry environment, the fluorescence quantitative PCR was used to determine the expression of matrix metalloproteinase 1 mRNA in bone tissue.RESULTS AND CONCLUSION:
The expression of matrix metalloproteinase 1 mRNA in bone tissue of smoking composite dry and cold environment group was higher than that of the smoking group (P < 0.05); the expression of matrix metalloproteinase 1 mRNA in bone tissue of smoking+pancreatic elastase composite dry and cold environment group was higher than that of the smoking+pancreatic elastase group (P < 0.01). It shows that dry and cold environment can exacerbate the damage of bone when compound with different diseases predisposing factors, such as smoking, smoking and pancreatic elastase.