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Abstract

BACKGROUND:

The degradation rate and strength of poly (lactic-co-glycolic acid) (PLGA) can be regulated by the addition of β-tricalcium phosphate (TCP), and the load of bone morphogenetic protein (BMP) can promote the osteoinductive capacity.

OBJECTIVE:

To test the effect of slow-release PLGA/β-TCP/isoniazid (INH)/BMP material on the repair of segmental radial defects in rabbits.

METHODS:

Forty New Zealand rabbits were collected and a rabbit model of 12-mm left radial defects was established. The rabbits were randomly divided into four groups: group 1, group 2, group 3 and group 4. The former three groups were implanted PLGA/β-TCP material, PLGA/β-TCP/INH material and PLGA/β-TCP/INH / BMP material, respectively. The group 4 served as the blank control group (without implants).

RESULTS AND CONCLUSION:

At week 12 after treatment, radial defects in the former three groups were all repaired well, and the PLGA/β-TCP/INH /BMP group obtained the best results (P < 0.05). The blank control group failed to restore radial defects. These results suggest that the slow-release PLGA/β-TCP/INH/BMP material can effectively repair the 12-mm long radial defects in rabbits.

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