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Nano-hydroxyapatite is a representative bioactive material, which has been the focus of tissue engineering research.


To review the orthopedic application and mechanism of nano-hydroxyapatite.


CNKI and PubMed databases (2001-01/2011-12) were retrieved for articles related to the effect of nano-hydroxyapatite on osteoblasts, osteoclasts, and revascularization to summarize the clinical progress of nano-hydroxyapatite in orthopedics.


Nano-hydroxyapatite can enhance the proliferation activity and functional metabolism of osteoblasts, and induce new bone formation. However, osteoclasts can absorb and degrade hydroxyapatite, and meanwhile, nano-hydroxyapatite can regulate osteoclast's metabolic processes and they influence each other in the bone metabolism. In addition, after implantation, nano-hydroxyapatite can be revascularized quickly and completely that is conducive to bone repairing and rebuilding. In view of the superiorities of nano-hydroxyapatite and its composite materials, nano-hydroxyapatite is an ideal material for repairing bone defects and has been preliminarily used in clinic. But there are still many problems to be solved in the future.

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