Bone marrow mesenchymal stem cells transplanted into diabetes mellitus rats can decrease glucose level.OBJECTIVE:
To summarize the research progress in bone marrow mesenchymal stem cells for promotion of islet regeneration.METHODS:
A computer-based online retrieval of PubMed and Wanfang databases was performed to search papers published during July 2003 to December 2011 with the key words bone marrow mesenchymal stem cells, islet cells in English and Chinese. Twenty-five papers were included in the final analysis.RESULTS AND CONCLUSION:
At present, transplantation of islets has made great advance in treatment of diabetes mellitus. Many patients with diabetes mellitus hardly benefit from islet transplantation because of limited islet origins and the immunological rejections of heterogenous or xenogenous islets. Bone marrow mesenchymal stem cells are characterized by easy to operate, easy in vitro isolation, culture and purification, and multipotential differentiation. Islets induce-differentiated by bone marrow mesenchymal stem cells are expected to solve islet-related problems of the limited origin and immunological rejections. This paper summarizes the research progress in bone marrow mesenchymal stem cells for treatment of diabetes mellitus and points out the existing problems and further study direction.RESULTS AND CONCLUSION:
Fan ZY, Bai JB, Wang H, Qie HZ, Deng XS, Hu Y, Liang HS, Wang LF, Wang S, Liu ZL. Research progress in bone marrow mesenchymal stem cells for promotion of islet regeneration. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(1):118-123.