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Abstract

BACKGROUND:

Transplantation of bone marrow mesenchymal stem cells shows great potential in repair of hippocampal injury. However, low survival rate of transplanted stem cells remains unsolved.

OBJECTIVE:

To summarize the protective effects of traditional Chinese medicine on bone marrow mesenchymal stem cells transplanted in the hippocampus of rats with post-traumatic stress disorder.

METHODS:

The databases of Pubmed, and CNKI were retrieved for papers published from January 2000 to January 2012 with key words “mesenchymal stem cells, transplantation, survival and post-traumatic stress disorder (PTSD), hippocampus” in English and Chinese. A total of 109 papers were retrieved. Among them, 23 papers were included in the final analysis.

RESULTS AND CONCLUSION:

Post-traumatic stress disorder is a complex disease influenced by biological, psychological, social and other factors and remains unsolved in treatment. Traditional Chinese medicine exhibits a unique advantage in this research field. Hippocampal damage caused by post-traumatic stress disorder can be repaired by transplantation of bone marrow mesenchymal stem cells. Bone marrow mesenchymal stem cell transplantation combined with intervention of Xiaoyaosan, a traditional Chinese medicine, is expected to increase the survival rate of transplanted stem cells.

RESULTS AND CONCLUSION:

Fu WJ, Ao HQ, Zeng L, Xu ZW. Protective effects of traditional Chinese medicine on mesenchymal stem cells transplanted into the hippocampus of rats with post-traumatic stress disorder. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(1):137-141.

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