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The use of cloned human embryos gives rise to ethical issues and allows scientists to find alternative ways to reverse differentiation of cells into multi/pluripotent stem cells, which is known as reprogramming. The new method of reprogramming is the focus of attention.


To investigate the current status of reprogramming and review the methods of somatic cell reprogramming into stem cells.


Using the database of CNKI and Pubmed (1983-01/2006-12) to search the related articles about reprogramming. The retrieval words include reprogramming, method, somatic cell, stem cell, differentiation. Papers related reprogramming published recently or in high-impact journals were initially surveyed and 17 papers were included in the final analysis.


The reprogramming of a pluripotent stem cell is the consequence of gradual reconstruction of cell structure, genetic change of chromatin, transcription expression and posttranscriptional control. Remodeling of targeted cells requires a stable status of reprogramming and a final reorientation into specific differentiation. Sufficient evidence demonstrates that cell identification is influenced by in vitro operation. The fate of reprogrammed cells needs further in vivo determination.


Ruan GP, Wang JX, Yang XY, Song QQ, Yao X, Pang RQ, Pan XH. Research progress in reprogramming somatic cells into stem cells. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(1):156-160.

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