Mesenchymal stem cells (MSCs) have become an ideal source of seed cells used for tissue-engineered trachea because they have good biological characteristics.OBJECTIVE:
To summarize the current research progress, existing problems and clinical prospects of mesenchymal stem cells used for reconstruction of tissue-engineered trachea.METHODS:
A computer-based online retrieval of Pubmed and CNKI databases was performed to search papers describing tissue-engineered trachea published during 1979-2012 using the key words “mesenchymal stem cells, tissue-engineered trachea, tracheal chondrocytes, tracheal epithelial cells, tracheal vascular endothelial cells” in English and Chinese. In the same research field, papers published recently or in high impact factor journals were selected. Fifty-one papers were included in the final analysis.RESULTS AND CONCLUSION:
Seed cells used for tissue-engineered trachea primarily include chrondrocytes, epithelial cells and vascular endothelial cells. Studies have demonstrated that mesenchymal stem cells can be differentiated into chondrocytes and cytokines play a key role in induced chondrogenic differentiation of mesenchymal stem cells. At present, there have been no proper factors that can be used to induce mesenchymal stem cells to differentiate into tracheal epithelial cells. Mesenchymal stem cells have been shown to exhibit the potential to differentiate into epithelial cells. Mesenchymal stem cells can be induced to differentiate into vascular endothelial cells under in vivo or in vitro special conditions, which provides experimental evidence for reconstruction of tissue-engineered trachea by vascular endothelial cells differentiated from mesenchymal stem cells.RESULTS AND CONCLUSION:
Tan RB, Shi HC. Current research and application prospect of mesechymal stem cells in tissue-engineered trachea. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(10):1884-1890.