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Abstract

BACKGROUND:

Differentially expressed microRNA plays an important role in proliferation and differentiation of osteoblasts. However, the underlying mechanism and possible targets are poorly understood.

OBJECTIVE:

To review the recent research progress of the role of microRNA in osteogenic differentiation of bone marrow mesenchymal stem cells by Wnt signaling pathway.

METHODS:

A computer-based online retrieval of CNKI and Pubmed databases was performed to search papers describing the role of microRNA in osteogenesis published during January 2000 to January 2012 using key words “microRNA, Wnt signaling pathway, osteogenesis”. In the same research field, papers published recently or in high impact factor journals were selected. A total of 205 papers were initially retrieved, and 33 were suitable for final analysis.

RESULTS AND CONCLUSION:

MicroRNA is increasingly searched in the field of life science. Accumulative evidence exists that microRNA plays an important role in osteogenic differentiation via Wnt signaling pathway. A better understanding of the mechanism by which RNA regulates osteogenic differentiation is the basis for culture of tissue-engineered bone and shows great application prospect. At present, the research of microRNA is still in its infancy.

RESULTS AND CONCLUSION:

Zou HL, Guo YF, Liu Y. Role of microRNA and Wnt signaling pathway in osteogenic differentiation of bone marrow mesenchymal stem cells. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(10):1896-1900.

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