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A way to build psychological stress is restraint stress.To study the relationship of restraint stress and type 1 diabetes.Forty-eight male Sprague-Dawley rats underwent intraperitoneal injection of streptozotocin to rat models of type 1 diabetes mellitus. After the successful modeling, rats were randomly divided into two groups: stress group (the rats were exerted with restraint stress) and control group (no intervention). Six rats from either group were executed at 1, 2, 3 and 4 weeks after exerting stress, and the related stress markers were detected, including the levels of adrenal cortical hormone, corticosterone and glucagon in the serum. Fasting blood glucose was measured regularly in rats.In the stress group, the levels of glucose and glucagon, after a week of the stress, were higher than those in the control group (P < 0.05 or P < 0.001). Simultaneously, the levels of adrenal cortical hormone and corticosterone in serum were higher in the stress group compared with the control group (P < 0.05 or P < 0.001). These indicate that restraint stress can raise the blood sugar level of diabetic rats.Wei GX, Wan ZX, Dai HW, Wang M. Restraint stress effects in type 1 diabetes rats. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(11): 1946-1950.