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Type II collagen and chondroitin sulfate are the major components of articular cartilage. They cannot only protect the cartilage, but also inhibit pathology of osteoarthritis.


To evaluate the curative effect of type II collagen injection and type II collagen- chondroitin sulfate composite injection on osteoarthritis by detecting the expression of rheumatoid factor and C-reactive protein.


A rat model of knee osteoarthritis was established by using improved Hulth's method. The treatment was performed via injection into the articular cavity (treatment group A: type II collagen injection; treatment group B: type II collagen-chondroitin sulfate composite injection; positive control: sodium hyaluronate; model control: physiological saline). After operation, rats in each group were characterized with daily observation, weighing, serum antibody test and histological observation.


After treatment, the content of rheumatoid factor and C-reactive protein in rats' serum of model group was increased, and inflammation was aggravated; while compared with the model group, the content of rheumatoid factor and C-reactive protein in the other groups, especially in the treatment group B, were lower and the inflammation was eased (P < 0.01). The findings show that both type II collagen and sodium hyaluronate can prevent and treat osteoarthritis effectively. The therapeutic effect of type II collagen combined with chondroitin sulfate is better.


Lei J, Zhong CH, Chen DC, Huang L. Expression of rheumatoid factor and C-reactive protein during type II collagen treatment of osteoarthritis. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(11): 2007-2012.

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