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Studies have shown that osteopontin is closely related to cartilage degeneration of osteoarthritis, but the osteopontin expression in the synovium and their relations to osteoarthritis severity are still rarely reported.


To investigate osteopontin effects on the occurrence and development of primary knee osteoarthritis.


Synovium samples from patients with knee osteoarthritis and low-limb trauma controls were enrolled in this study. The comprehensive score method was taken for grouping. Osteopontin levels in the synovium were measured using immunohistochemical method. The differences among groups were compared. The level of osteopontin between the synovial lining layer and the sub-lining layer was also compared.


In the tissue of osteoarthritis, positive expression of osteopontin was found, showing yellow, burry, and brown in color. Compared to the controls, osteoarthritis patients had higher osteopontin level in the synovium (P < 0.05). In addition, subsequent analysis showed that osteopontin levels in the synovium were significantly correlated with severity of disease (ρ=0.663, P < 0.01). There was no significant difference in the osteopontin level between the synovial lining layer and the sub-lining layer (P > 0.05). These data suggest that osteopontin may be associated with the pathogenesis of osteoarthritis.


Xiao SS, Gao SG, Xu M, Zhang K, Zhu HY, Song Y, Yang Y, Lei GH. Expression of osteopontin in the articular synovium of human knee osteoarthritis. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(11): 2013-2019.

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