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Abstract

BACKGROUND:

In vitro culture of osteoblasts and its Chinese medicine intervention is one of the important means for the research and development of osteoporosis treated with traditional Chinese medicine.

OBJECTIVE:

To observe the effect of Chinese medicine on the proliferation and differentiation of osteoblasts and the synthesis of osteocalcin.

METHODS:

The researches on the effect of different kinds of Chinese medincine-loaded serum on the secretion of osteoblasts and osteocalcin were collected for the data analysis. The effect of traditional Chinese medicine on osteocalcin synthesis of osteoblasts was observed from the level of molecular cell biology.

RESULTS AND CONCLUSION:

Some single Chinese herbs and Chinese herbal compounds could promote the proliferation and differentiation of osteoblasts and the synthesis of osteocalcin, and different Chinese medicines had different effects in promoting the proliferation and differentiation of osteoblasts and expression level of osteocalcin, which was positively correlated with the concentration of Chinese medicine-loaded serum. Through screening with the in vitro culture of osteoblasts, the drugs and appropriate dose for promoting the proliferation and differentiation were founded, which could positively promote the development of drugs used for the treatment of osteoporosis.

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