Symbol: Self-made Fe3O4versusgelatin sponge embolic agents in rabbit pulmonary microcirculation

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Abstract

BACKGROUND:

Studies have shown that small-particle embolic agents can easily perform embolization by micro-catheter, and the arterioles can be embolized well by 50-100 μm particles to reduce collateral circulation generation.

OBJECTIVE:

To observe the pathological changes following embolizing rabbit pulmonary microcirculation with self-made embolic agents.

METHODS:

Self-made Fe3O4 fine particles with a size of 50, 100, 150, 200, 250 μm and self-made gelatin sponge with a diameter of 500-1 000 μm were employed for interventional embolism of the pulmonary artery from New Zealand white rabbits. Then, the embolic effect was observed.

RESULTS AND CONCLUSION:

Angiography and pathological results showed that 50, 150, 250 μm Fe3O4 fine particles and gelatin sponge particle could embolize to different-diameter microcirculatory blood vessels. Fe3O4 fine particles could result in the embolization of rabbit capillaries and precapillary arterioles until 1-4 weeks after interventional embolism, indicating that Fe3O4 fine particle had a long-time embolism effect. Fe3O4 fine particles could also pass though the microtubule, and no ectopic embolization was visible. Gelatin sponge particles that were unable to pass through the microtubule could block the small arteries with a diameter of (1 300±348) μm. Gelatin sponge particles could be absorbed within 1-2 weeks after embolization. These findings suggest that Fe3O4 particles have good embolic effect that is persistent and complete, and it is difficult to vascular recanalization and establishment of collateral circulation after embolization. Gelatin sponge as an embolic agent is suitable for branches and small arteries rather than the microcirculation.

RESULTS AND CONCLUSION:

Yang Q, Tong YY, Guo L, Wang JP, Li YC, Jiang H. Self-made Fe3O4 versus gelatin sponge embolic agents in rabbit pulmonary microcirculation. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(12): 2091-2099.

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