Previous studies have successfully prepared nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol-5-fluorouracil.OBJECTIVE:
To discuss the effect of nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol-5-fluorouracil composite on bone defect repair and against bone tumor.METHODS:
Bone tumor models were induced by injection of VX2 carcinoma cell suspension into the medullary cavity of right tibias in 72 New Zealand white rabbits through the knee joints. Partial resection of the tibia was performed to form bone defects that were adjacent to bone tumors. After modeling, all the rabbits were randomized into experimental and control groups. Nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/ polyethylene glycol-5-fluorouracil and nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/ polyethylene glycol artificial bone were implanted into bone defects, respectively, in the experimental and control groups.RESULTS AND CONCLUSION:
(1) Inorganic content was decreased gradually in the two groups, especially in the experimental group. (2) X-ray examination: At 24 weeks after implantation, the implant became smaller than that in the early stage after implantation. However, there were no changes in the implant volume in the control group, and tumor volume in the control group was enlarged progressively. (3) Biomechanical detection: At 24 weeks after implantation, the maximal torque of the lower limbs in the experimental group was significantly higher than that in the control group (P < 0.01). (4) Bone mineral density in the two groups was firstly decreased and then increased at 2-24 weeks after implantation. The changes in the bone mineral density of the experimental group were significant. (6) Tumor volume was decreased in the experimental group and increased in the control group at 24 weeks after implantation. These findings indicate that nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol-5-fluorouracil can perfectly repair bone defects and exert a remarkable effect against tumor growth.RESULTS AND CONCLUSION:
Feng W, Jin AM, Liu JE, Gou RE, Guan CH, Liang QF, Xin RB. Antitumor effect of 5-fluorouracil microsphere composite on bone defect repairs. Zhongguo Zuzhi Gongcheng Yanjiu. 2013;17(12):2131-2137.