A perfect repairing material is necessary to improve the quality of life in staged repair of Tetralogy of Fallot to enlarge the right ventricular outflow tract that is serious narrow. The materials currently used for outflow tract widening include biological patch and man-made fabric patch.OBJECTIVE:
To compare the effects of tissue-engineered bovine pericardium patch and Dacron patch in staged repair of Tetralogy of Fallot to widen the right ventricular outflow tract.METHODS:
Twenty-five patients with Tetralogy of Fallot who had undergone the first-stage shunt operation were divided into two groups according to the date of second stage surgery. Polyester-made artificial blood vessel patch group included 14 cases, and the right ventricular outflow tract was enlarged with polyester-made artificial blood vessel patches (from April 2007 to July 2010); tissue engineered bovine pericardium patch group included 11 cases, and the right ventricular outflow tract was enlarged with bovine pericardium patches (from August 2010 to September 2011). Clinical effects of the two groups in the early stage postoperation were compared.RESULTS AND CONCLUSION:
There was one case of postoperative death in the polyester-made artificial blood vessel patch group. Ventilator time, the ratio of right ventricular pressure and left ventricular pressure, the pressure gradient across the right ventricular outflow tract, the pericardial cavity drainage volume, ICU time and length of hospital stay in the bovine pericardium patch group were less than those in the polyester-made artificial blood vessel patch group (P < 0. 05). Tissue engineered bovine pericardium patch can be adapted as a better repairing material in staged repair of Tetralogy of Fallot to enlarge the right ventricular outflow tract.