The lung is suitable as a local or systemic administration site because of its special physiological structure, while there lacks reports on advantages of lung sustained-release microspheres for the treatment of lung diseases, even systemic diseases.OBJECTIVE:
To evaluate drug releasing property and safety of clinical administration of lung sustained-release microspheres, and to compare the difference between lung sustained-release microspheres and other pulmonary drug delivery dosage forms.METHODS:
The distribution and degradation of microspheres in the lung, pathological changes of the lung tissue and the effect of continuous administration on lung function were observed.RESUTLS AND CONCLUSION:
The materials commonly used for lung sustained-release microspheres included starch and polylactic acid. The lung sustained-release microspheres have the abilities of biodegradability, biocompatibility and bioadhesion. The sustained-release microspheres are easy to prepare and have no damage to the normal tissue with high security. The lung sustained-release microspheres have good lung targeting effects which can improve the drug efficacy, reduce the side effects of drugs and have no pathological damage to lung tissue.