Symbol: Performance and evaluation of lung sustained-release microspheres for the treatment of lung diseases

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Abstract

BACKGROUND:

The lung is suitable as a local or systemic administration site because of its special physiological structure, while there lacks reports on advantages of lung sustained-release microspheres for the treatment of lung diseases, even systemic diseases.

OBJECTIVE:

To evaluate drug releasing property and safety of clinical administration of lung sustained-release microspheres, and to compare the difference between lung sustained-release microspheres and other pulmonary drug delivery dosage forms.

METHODS:

The distribution and degradation of microspheres in the lung, pathological changes of the lung tissue and the effect of continuous administration on lung function were observed.

RESUTLS AND CONCLUSION:

The materials commonly used for lung sustained-release microspheres included starch and polylactic acid. The lung sustained-release microspheres have the abilities of biodegradability, biocompatibility and bioadhesion. The sustained-release microspheres are easy to prepare and have no damage to the normal tissue with high security. The lung sustained-release microspheres have good lung targeting effects which can improve the drug efficacy, reduce the side effects of drugs and have no pathological damage to lung tissue.

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