Smoking promotes the resorption of periodontal alveolar bone

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Abstract

BACKGROUND:

Various studies confirm that smoking can contribute to the resorption of periodontal alveolar bone.

OBJECTIVE:

To observe the effect of smoking in alveolar bone resorption of periodontitis rat models.

METHODS:

A total of 24 rats were randomly divided into three groups. Normal group: rats were normally fed without any other pre-treatment; Control group: experimental periodontitis model was established using wire ligation method in rats; Experimental group: rat models were given passive smoking during experimental modeling period. All rats were sacrificed after 8 weeks of modeling, periodontal tissue were removed. Hematoxylin-eosin staining was used for examining pathological changes in periodontal tissue, and immunohistochemical analysis was done for observing receptor activator of nuclear factor-κB ligand and osteoprotegrin expression.

RESULTS AND CONCLUSION:

After 8 weeks of modeling, expression of receptor activator of nuclear factor-κB ligand factor was significantly higher in alveolar bone of rats from experimental group in comparison to control group (P < 0.05), whereas expression of osteoprotegerin in alveolar bone was significantly greater in rats from control group when compared to experimental group (P < 0.05). This finding suggests that smoking can increase the expression of receptor activator of nuclear factor-κB ligand protein and reduce osteoprotegrin expression in periodontal rats, thus increasing the resorption of periodontal alveolar bone.

Subject headings: smoking; periodontitis; alveolar bone loss; NF-kappa B; osteoprotegrin

Zhu JH, Wang Y, Zhao ZN, Liu JG. Smoking promotes the resorption of periodontal alveolar bone. Zhongguo Zuzhi Gongcheng Yanjiu. 2014;18(20):3172-3177.

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