Molecular mechanism of osteoclast, bone resorption and fracture healing by V-ATPase a3 transport system

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Abstract

BACKGROUND:

The V-ATPase a3 transport system plays a crucial role on bone resorption mechanism of the osteoclasts.

OBJECTIVE:

To observe the expression of V-ATPase a3 transport system in fracture repair and the effect of V-ATPase a3 transport system inhibitor on fracture healing.

METHODS:

We retrieved related literatures in the periodicals database with the key words, and screen them according to the inclusion criteria. The literatures were included in this study after the evaluation of quality.

RESULTS AND CONCLUSION:

V-ATPase a3 transport system widely exists in the cytoplasm membrane and organelle membrane of eukaryotic cells. V-ATPase a3 has two structural domains: V0 and V1. V0 structural domain is the proton transport channel, V1 structural domain is mainly the hydrolysis of ATP. V-ATPase a3 transport system focuses on the frilled edge of osteoclasts, H+ is transported to form a high concentration, dissolves inorganic minerals and provides the acidic environment for hydrolytic enzymes, thus being involved in bone resorption. So V-ATPase a3 transport system is selected as the research target in the fracture repair and reshape.

Subject headings: V-ATPase a3; osteoclasts; fracture healing

Funding: the National Natural Science Foundation of China, No. 81360554; Clinical Research Special Funds by Wu Jieping Medical Foundation, No. 320.6750.11061; Science and Technology Project for Youth of Gansu Province, No. 1208RJYA066

Song M, Dong WT, Chen BH, Chai JT, Li YL, Wei H, Chen BX. Molecular mechanism of osteoclast, bone resorption and fracture healing by V-ATPase a3 transport system. Zhongguo Zuzhi Gongcheng Yanjiu. 2014;18(20):3257-3262.

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