There are an increasing number of studies addressing hydrogen sulfide as the third gaseous signal molecule, to regulate cellular function, but some contradictions emerge.OBJECTIVE:
To summarize the mechanism of hydrogen sulfide regulating cell function based on the current researches.METHODS:
A computer-based online search of the PubMed database (from 1990 to 2013) was performed, with the key words of “hydrogen sulfide, gasotransmitter” in English. Finally 54 related articles were included in the result analysis.RESULTS AND CONCLUSION:
Accumulating evidence has highlighted the contribution of hydrogen sulfide on regulating cell function, and the underlying mechanism is very complex. Traditional signal molecule (such as estrogen and neuromediators) may amplify the signals for signal transduction through a series of cascade reaction, but the gaseous signal molecule promotes cell metabolism through the post-transcriptional modification of intracellular target protein. The majority of studies indicate that hydrogen sulfide plays an antioxidant, anti-inflammatory and anti-apoptotic role in the physiological concentration, but there are some contradictions in terms of inflammation and apoptosis research. Therefore, further study on the mechanism of hydrogen sulfide should be implemented.
Subject headings: hydrogen sulfide; cystathionine-β-synthase; cystathionine-γ-lyase; inflammation; apoptosis
Funding: the National Natural Science Foundation of China (General Program), No. 81071504; Natural Science Foundation of Beijing, No. 7123231; the National Natural Science Foundation of China (Chief Program), No. 81241063
Wang SJ, Li YT, Sun HL, Li CD, Wang TL. Effect and mechanism of hydrogen sulfide in regulating cellular functions. Zhongguo Zuzhi Gongcheng Yanjiu. 2014;18(20):3275-3280.