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Abstract

BACKGROUND:

Collagen/bioactive glass composite materials possess excellent osteogenic potential and biocompatibility, but its application in bone tissue engineering is limited by mechanical property and degradation. OBJECTIVE: To construct collagen/bioactive glass/chitosan composite scaffolds with good mechanical property, anti-degradation ability and bone repair property.

METHODS:

Bioactive glass/collagen composite scaffolds with chitosan as dispersant were prepared by lyophylization. Fourier transform infrared spectroscopy, scanning electron microscope, X-ray diffraction, and dynamic biomechanical testing were used to characterize the structure and properties of the composite scaffolds.

RESULTS AND CONCLUSION:

Results show that charge-attractions in pre-prepared bioactive glass/chitosan solution increased the homogeneity of bioactive glass dispersed in collagen gel and the compressive modulus and strength increased significantly due to the homogeneity and intermolecular interactions between chitosan and collagen. The enzymatic degradation rate and mineralization activity in the simulated body fluid were also lower because of a high degree of embedment of bioactive glass in collagen/chitosan matrix, and entanglement of collagen in chitosan at molecular level, which decreased the exposure of bioactive glass to the simulated body fluid, and collagen to enzyme solution.

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