Cardiovascular biomaterials applied under the blood-contact conditions must haveBACKGROUND:
anti-thrombotic, anti-biodegradable and anti-infective properties.OBJECTIVE:
To develop novel polymer materials for implantation and intervention in cardiovascular tissueOBJECTIVE:
engineering and then to explore the biological, blood and cell compatibilities of corresponding surface-modifiedOBJECTIVE:
polymer biomaterials based on surface construction and biological response.METHODS:
We retrieved PubMed and WanFang databases for relevant articles publishing from 1984 to 2013.METHODS:
The key words were “biocompatibility, blood compatibility, biomedical materials, biomedical polymer materials” in English and Chinese, respectively.RESULTS AND CONCLUSION:
Here, we analyze the following four aspects: protein adsorption, biometric identification in cell adhesion, and the “waterfall model” for enzyme catalysis during blood coagulation and fibrinolysis. Consequently, it is concluded that the functional surface construction of polymer biomaterials and research on corresponding biocompatibility and endothelial cell compatibility are crucial for developing novel polymer materials for implantation and intervention in cardiovascular tissue engineering. Through in-depth studies of the types and applications of polymer biomaterials, cardiovascular medical devices and implantable soft tissue substitutes, the differences between the surface and the body will be reflected in the many layers of molecules extending from the surface to the body. Two major factors, surface energy and molecular mobility, determine the body/surface behaviors that include body/surface differences and phase separation. Considering the difference between body/surface composition, an additional determinant is indispensable, that is the crystallization behavior of each component.