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Modification with peptides to mimic the functional proteins of extracellular matrix can promote adhesion and spreading of endothelial cells, and facilitate endothelialization.


To review the studies concerning the modification with peptides in the endothelialization of cardiovascular implants in recent years, and to provide the new ideas for relative research.


The PubMed database was retrieved with computer from January 1990 to December 2013 for the articles on peptides modification to facilitate endothelialization. The key words were “peptides, surface modification, endothelialization”. Finally, 43 articles were included for review according to the inclusion and exclusion criteria.


Peptides derived from extracellular matrix proteins are used to modify cardiovascular materials, which can improve the adhesion of endothelial cells, and also avoid the defects by directly employing the natural extracellular matrix components. Nonspecific peptides, including RGD and YIGSR, can promote the adhesion of a variety of cell types including endothelial cells. Specific peptides, including REDV, CAG and SVVYGLR, can selectively promote endothelial cell adhesion and spreading. Surface modification with specific peptides can specifically promote endothelialization of biomaterials. The combined application of specific peptides with other biological information molecules or several peptides may be the alternative approach to promote endothelialization of cardiovascular implants.

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