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In patients with primary bone tumor around the knee joint, deep venous thrombosis easily occurred after prosthetic implantation, lesion resection/curettage, bone grafting and plate fixation. Thus, this should be paid enough attention in the clinic.


To explore effectiveness and safety of rivaroxaban to prevent the deep vein thrombosis of adult lap in patients with primary bone tumors undergoing prosthetic replacement or plate fixation after resection/curettage tumors.


Forty adult patients with primary bone tumor around the knee joint diagnosed in Department of Bone and Soft Tissue Oncology, Xijing Hospital, Fourth Military Medical University of Chinese PLA from March 2011 to March 2012 were randomly enrolled in this study. They did not have affected deep venous thrombosis before treatment. They were randomly assigned to two groups. Control group (n=20) received lesion resection/curettage, prosthetic replacement or plate fixation, and then received usual care and physical prophylaxis. Treatment group (n=20) received rivaroxaban 10 mg/d orally for 14 days, besides the treatment in the control group. At 1 month after treatment, deep venous thrombosis and the incidence of deep venous thrombosis were evaluated in follow-up. Whether pulmonary embolism and severe hemorrhage occurred was observed in both groups.


None deep venous thrombosis developed in the treatment group, however, two patients with deep venous thrombosis were found in the control group. There was no pulmonary embolism or severe hemorrhage in both groups. There was significant difference in the incidence of deep venous thrombosis between both groupsP (< 0.05). Results suggested that rivaroxaban effectively reduced the occurrence of deep venous thrombosis in the patients with primary bone tumor around the knee joint, and showed good prevention and safety.


Wang Q, Wang Z, Guo Z, Chen GJ, Wang CR, Lin Y, Wu ZG. Anticoagulant after prosthetic implantation or plate fixation for resection/curettage of primary bone tumor around the knee joint: effect of rivaroxaban. Zhongguo Zuzhi Gongcheng Yanjiu. 2014;18(22):3456-3462.

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