Mental health status of relative donorsversusunrelated donors before and after hematopoietic stem cell collection

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Abstract

BACKGROUND:

Currently, hematopoietic stem cell transplantation mainly depends on unrelated donors. Mental state of the unrelated donors is very important to ensure the successful cell transplantation.

OBJECTIVE:

To compare mental and physical health status of relative and unrelated donors during the hematopoietic stem cell collection.

METHODS:

We compared the mental (Symptom Checklist-90) and physical (temperature, breath, pulse, and blood pressure) health status of relative and unrelated donors at admission, 1 day before cell collection, and 1-2 days after cell collection.

RESULTS AND CONCLUSION:

At admission, there was no difference in the mental health status of relative and unrelated donors (P > 0.05), while the scores on Symptom Checklist-90 were significantly higher in the unrelated donors than the relative donors, including total score, forced, depression, anxiety, hostility, and fear (P < 0.05). The physical signs were steady in the unrelated and relative donors, but the difference in breath and systolic blood pressure was of great significance before and after cell collection in the two groups. These findings indicate that during cell collection, the unrelated donors exhibit heavier mental load than the relative donors, and psychological counseling and health guidance are necessary.

Subject headings:

hematopoietic stem cell transplantation; stress, psychological; fear; anxiety

Funding:

the grant from Beijing Marrow Donor Program, No. PXM2011_077203_113500

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