Safety analysis of umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of cerebral palsy in children

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Abstract

BACKGROUND:

Umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of children with cerebral palsy is a clinical hotspot.

OBJECTIVE:

To analyze the efficacy and safety of umbilical cord blood stem cell transplantation combined with nerve growth factor in the treatment of cerebral palsy in children.

METHODS:

A total of 80 children with cerebral palsy admitted at the Department of Pediatrics, Hongqiao Hospital of Tianjin, China from 2011 November to 2013 February were enrolled, and according to therapeutic methods, they were divided into experimental group (n=40; treated with umbilical cord blood stem cell transplantation combined with nerve growth factor) and control group (n=40; treated with nerve growth factor alone).

RESULTS AND CONCLUSION:

After treatment, scores on comprehensive function assessment scale and gross motor function measure scale were significantly increased in the two groups (P < 0.05), while white cell count, neutrophil fraction, and levels of total bilirubin, alanine aminotransferase and aspartate aminotransferase were also increased (P < 0.05). Moreover, the experimental group showed a better outcome than the control group after treatment (P < 0.05). All of the patients had no serious adverse reactions. Umbilical cord blood stem cell transplantation combined with nerve growth factor has dramatic curative effects in children with severe cerebral palsy significant curative effect, with high safety.

Subject headings:

cerebral palsy; cord blood stem cell transplantation; nerve growth factor; comparative effectiveness research

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