Differential expression of angiogenic growth factors in cerebrovascular malformations

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Abstract

BACKGROUND:

Cerebral vascular malformations are the leading cause of hemorrhagic apoplexy in young adults, and the rupture and bleeding of malformed vessels may cause severe neurological dysfunction. The mechanism of cerebral vascular malformations remains unclear. Modern molecular biology studies have shown that, angiogenic growth factors are abnormally expressed in cerebral vascular malformations.

OBJECTIVE:

To evaluate differences in the expression of angiogenic growth factors in cerebral vascular malformations, and discuss the possible relationship between cerebral vascular malformations and angiogenic growth factors.

METHODS:

Fifty patients with cerebral vascular malformations and fifty patients with intracerebral hemorrhage were included in this study. The expressions of angiogenic growth factor (vascular endothelial growth factor and transforming growth factor-α) in the cerebral vascular malformation specimens and the normal superficial temporal artery specimens were detected with immunohistochemical staining.

RESULTS AND CONCLUSION:

In the normal superficial temporal artery of intracerebral hemorrhage patients, no expression of vascular endothelial growth factor and transforming growth factor-α was found; in the vascular malformations, they were highly expressed (P < 0.05). Compared with normal blood vessels, vascular endothelial growth factor and transforming growth factor-α expression was significantly increased in patients with cerebral vascular malformations.

Subject headings:

vascular endothelial growth factors; transforming growth factor-α; intracerebral hemorrhage; arteriovenous malformation

Funding:

Scientific Research Foundation of the First Affiliated Hospital of Xinjiang Medical University, No. 2012YFY20

Funding:

Zhu GH, Yang ZC, Dang MR, Maimaitili, Wang X, Serickduysenbi. Differential expression of angiogenic growth factors in cerebrovascular malformations. Zhongguo Zuzhi Gongcheng Yanjiu. 2014;18(29):4689-4694.

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