Effects of telmisartan on endothelial progenitor cells and high sensitive C-reactive protein in patients with unstable angina pectoris

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Abstract

BACKGROUND:

Atherosclerotic plaque is chronic low-level inflammation in human body. Telmisartan can lower blood pressure, protect the target organs and inhibit inflammation, also partially activate peroxisome proliferator-activated receptor γ, increase the number of progenitor cells, and inhibit inflammation of vascular wall cells.

OBJECTIVE:

To observe the effects of telmisartan on endothelial progenitor cells and high-sensitivity C-reactive protein in peripheral blood of patients with unstable angina pectoris.

METHODS:

200 patients with unstable angina pectoris who consulted the doctors of the First People's Hospital of Neijiang from January 2012 to December 2013 were randomly divided into contrast group and telmisartan group, with 100 patients in each group. The general clinical data of each patient was collected. Peripheral venous blood was taken before treatment and 4, 8 weeks after treatment. Endothelial progenitor cells and high-sensitivity C-reactive protein level were detected.

RESULTS AND CONCLUSION:

At 4 and 8 weeks after treatment, the percentage of endothelial progenitor cells in telmisartan group was significantly higher than those before treatment and that of contrast group (P < 0.05). At 4 and 8 weeks after treatment, the high-sensitivity C-reactive protein level was decreased significantly in telmisartan group compared with before treatment. The telmisartan group had a significantly lower level than the contrast group (P < 0.05). Telmisartan can promote the proliferation of endothelial progenitor cells and restoration of damaged vessels. It can also reduce high-sensitivity C-reactive protein level and inhibit the inflammatory reaction.

Subject headings:

unstable angina pectoris; telmisartan; endothelial progenitor cells; high sensitive C-reactivity protein; treatment

Funding:

Natural Science Foundation of Sichuan Provincial Science and Technology Department, No. 05JY029-105-1

Funding:

Ni W. Effects of telmisartan on endothelial progenitor cells and high sensitive C-reactive protein in patients with unstable angina pectoris. Zhongguo Zuzhi Gongcheng Yanjiu. 2014;18(29):4701-4705.

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