P58The relationship between angiotensinogen gene polymorphism and left ventricular remodeling in patients with myocardial infarction

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Abstract

Purpose

The development of left ventricular (LV) remodeling after acute myocardial infarction (AMI) is a predictor of heart failure and mortality. The purpose of the present study was to assess whether the polymorphism of angiotensinogen (AGT) gene with threohine (T) instead of methionine (M) at amino acid 235 in exon 2 (M235T) had effects on cardiac remodeling after AMI.

Methods

141 patients (mean age 56.4 ± 11.1) with a first AMI were enrolled. Within 24-72 hours of the onset of AMI symptoms and at 4 months, 2-dimensional echocardiography was performed. LV remodeling was defined as ≥15% increase from the baseline in LV end diastolic volume. AGT M235T polymorphism was determined using polymerase chain reaction amplification.

Results

At follow-up, 49 patients (34.7%) were classified as having LV remodeling. Patients with LV remodeling were more frequently prone to anterior wall MI (p < 0.01), higher leukocyte count value at admission (p < 0.01), lower LV ejection fraction (p < 0.05) and increased LV end systolic volume (p < 0.05). Furthermore, AMI patients with LV remodeling significantly more often were carriers of TT genotype of AGT gene (28,6% vs.14.1%, p=0.038).

Conclusions

The TT genotype of the AGT gene may be related to the development of LV remodeling after acute myocardial infarction.

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