Premature coronary heart disease(CHD) is a highly complex disorder with multiple risk factors.Objective
To identify the risk factors responsible for premature (CHD) in local population.Method
A case control study of 100 angiographically diagnosed patients and 100 healthy subjects was conducted. The risk factors assessed in this study were Serum Lipids, Lipoprotein and Apolipoprotein-A1,Apolipoprotein-B, Lp(a), Diabetes Mellitus (DM), smoking, hypertension,family history of CAD, obesity and sedentary lifestyle. Descriptive,uni-variate and multivariable analyses were conducted using statistical package for social sciences (SPSS).Results
Sedentary life style (OR= 12.57, 95% CI: 3.68, 42.98), serum Triglyceride (TAG) levels(OR= 2.45, 95% CI: 1.27, 4.72), HDL-c (OR= 4.95, 95% CI: 2.35, 10.42), APO-A(OR= 1.86, 95% CI: 4.40, 24.76), APO-B (OR= 10.49, 95% CI: 4.40, 24.76) andlipoprotein (a) (OR= 2.15, 95% CI: 1.20, 3.84) were found to be significant factors.TAG levels, HDL-c, APO-A, LDL-c and HDL-c ratio, total cholesterol and HDL-cratio were found to be significant among patients of age ≥40 years, while LDL-capolipoproten B and LP(a) was highly significant among age < 40 years.Conclusion
Raised level of Lp(a), apo-B and LDL-c among premature CAD patients have identified as risk factors in Pakistani adults < 40years.