P180The influence of beta1-adrenergic receptor gene polymorphism on lipids metabolism in patients with heart failure and systolic dysfunction

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Abstract

Purpose

To investigate the influence of Ser49Gly and Arg389Gly β1-adrenergic receptor (β1-AR) gene polymorphism on lipids metabolism in patients with severe chronic heart failure.

Methods

Ninety nine patients (78 males and 21 females; mean age 61,7 ± 0,96 years) with chronic heart failure and systolic dysfunction were examined. Geno-typing was performed to identify the individual β1-AR Arg389Gly and Ser49Gly polymorphism by the restriction fragment length analysis of polymerase chain reaction products. The parameters of lipid metabolism were determined enzymatically by using kits of reagents "HUMAN" (Germany), according to manufacturer's instructions. Taking into account the abnormality of distribution non-parametric tests were performed. Results were present as Median (low : upper quintiles). For nonparametric comparisons Mann-Whitney U test was used. All statistical tests were 2-tailed, and p < 0.05 was considered statistically significant.

Results

Serum total cholesterol ((5,61 (5,00 : 6,37) versus 4,60 (3,81 : 5,58) mmol/l), triglycerides ((2,13 (1,64 : 2,47) versus 1,64 (1,14 : 1,98) mmol/l), low-density lipoprotein (LDL) cholesterol ((3,63 (3,14 : 4,33) versus 2,88 (2,18 : 3,58) mmol/l) and very low-density lipoprotein (VLDL) cholesterol ((0,96 (0,74 : 1,11) versus 0,74 (0,51 : 0,89) mmol/l) were significantly higher in the group of Ser49Gly carriers than in the homozygous carriers of Ser49 allele of β1-AR gene polymorphism, (p < 0,01). The concentration of serum total cholesterol ((5,00 (4,20 :5,96) versus 4,17 (3,91 : 4,60) mmol/l), triglycerides ((1,78 (1,37 : 2,12) versus 1,50 (0,9 :2,00) mmol/l), LDL cholesterol ((3,13 (2,34 : 4,09)) versus 2,60 (2,42 :3,04) mmol/l) and VLDL cholesterol ((0,80 (0,62 : 0,95)) versus 0,68 (0,44 6 0,90) mmol/l) were higher in the group of Arg389Arg carriers than in the homozygous carriers of Gly389 allele of β1-AR gene polymorphism but these differences didn't reach a significance, (p > 0,05)

Conclusions

The presents of Ser49Gly β1-AR gene polymorphism was associated with significantly greater lipids metabolism abnormalities comparing with the Gly49Gly variants. The Arg389Gly polymorphism wasn't influence on lipids metabolism in the patients with severe chronic heart failure.

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