P190Telomere length in metabolic disorders in group of survivors of Leningrad Siege

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Abstract

Purpose

The impairment of perinatal nutrition could promote the development of metabolic disorders and cardiovascular complications in the adult life. Contradictive results have also been reported on intrauterine starvation influence on telomere length what is one of the discussed markers of metabolic disorders and it has been found to be shortened in subjects with obesity, insulin resistance, arterial hypertension. The aim of our study was to assess the metabolic state and telomere length in subjects who survived of Leningrad Siege during second World War (1941-1944) comparing to control group of the same age.

Methods

189 survivors of Leningrad Siege (54 males, 135 females) were examined on EVA syndrome. In 36 of Siege survivors (13 males, 23 females) and 12 controls (6 males, 6 females) the telomere length was also examined. The patients were divided in two groups: born before the Leningrad Siege (157 subjects) and during the Leningrad Siege (32 subjects). Informed consent was obtained from all participants. All participants were interviewed by special questionnaire regarding lifestyle and risk factors. Blood pressure was measured on right arm in the sitting position after 5 minute of rest two times. Anthropometry were performed according to standard procedures. Fasting serum lipids and plasma glucose were measured on Hitachi-902. Relative telomere lengths were measured by qRT-PCR, the ratio of telomere repeat copy number to single gene copy number (T/S) was calculated for each DNA sample.

Results

The telomere lengths in the survivors of Leningrad Siege group was significantly shorter compared to the controls: relative T/S values was 0,78 ( ± 0,05) vs. 0,69 ( ± 0,04) for controls group; p < 0,005.

Conclusions

Survivors who were born during the Leningrad Siege had higher prevalence of metabolic disorders. Starvation in late gestation and early perinatal period predict short telomere length and promote the development of metabolic syndrome.

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