P191Mitral valve prolapse and sudden cardiac death. Is there a cardiomyopathy linked to floppy mitral valve?

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Mitral valve prolapse (MVP) is a relatively common disorder of the mitral valve and most cases take a benign clinical course. This condition is common in the elderly but also recognised in the young, rarely leading to a sudden cardiac death (SCD). The aim of our study was to assess the frequency, demographics and histologic myocardial abnormalities in patients with MVP and SCD.


A retrospective study of MVP and SCD referred to our tertiary referral centre during the period of 1994-2010.


A total of 39 cases of sCD with MVP were identified with a similar distribution by gender; 1:1.3 (M:F), median age 37, range 19-79 years. MVP was associated with left ventricular myocardial fibrosis in over half of the cases (n = 22, 56%) predominately in females (63%, n=14). Left ventricle hypertrophy (LVH) (n = 11, 28%) alone (n = 2) or with fibrosis (n = 9) was also common with MVP. The myocardium was normal in 6 cases.


Abnormalities of the myocardium, of which fibrosis was the most common, were present in 85% of cases raising the question of a possible link of MVP to cardiomyopathy. It is also possible that the floppy valve change is secondary to the cardiomyopathy.

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