P215Bitter agonists increase vascular tonus immediately after intake

    loading  Checking for direct PDF access through Ovid

Abstract

Introduction

Digestion of food involves

Introduction

• the production and secretion of enzymes

Introduction

• Splanchnic circulation increases: 1) to support the digestive organs by increasing cellular nutrition and removing waste products and; 2) to remove digested compounds from gastrointestinal tissues.

Introduction

splanchnic increases are referred to as post-prandial hyperaemia and begin immediately after food intake. Bitter agonists are traditionally used in numerous Eurasian cultures to aid digestion. We investigated whether the two bitter agonists gentian (Gentiana lutea) and wormwood (Artemisia absinthium) impacted on vascular tonus. Gentian is used in central European alpine areas for the production of aperitifs. Wormwood is used in the production of the aperitif vermouth which is popular in Mediterranean countries and is a key ingredient of martinis in North America.

Introduction

Method: Three groups of 13 healthy non-medicated participants were tested in a randomised double-blinded procedure with 70 mL water and:

Introduction

• Group1 - three different sets of capsules containing: placebo (cellulose) control, 1000 mg gentian and 1000 mg wormwood.

Introduction

• Group2a – 1 mL of fluid extracts containing either 500 mg or 1500 mg gentian; and

Introduction

• Group2b - 1 mL of fluid extracts containing either 500 mg or 1500 mg wormwood.

Introduction

Continuous cardiovascular measurements were obtained with the Finometer for five minutes pre- ingestion and 30 minutes post-ingestion. Measures from three post-ingestion periods: P1 (0 to 5 minutes), P2 (10 to 15 minutes) and P3 (25 to 30 minutes) were compared to pre-ingestion measures with the Group1 placebo capsule condition measures acting as the control.

Statistical analysis

Group1 Repeated measures ANOVA and Groups 2a and 2b ANCOVA.

Results

Group1: the capsules elicited no vascular changes.

Results

Group2a: gentian fluid extracts increased peripheral resistance in P1 (1500 mg, p = 0.020) and P2 (500 mg, p = 0.019).

Results

Group2b: during P1 wormwood 1500 mg fluid extract decreased arterial compliance (p = 0.004) and increased diastolic pressure (p = 0.005).

Conclusion

Encapsulated gentian and wormwood did not elicit vascular responses when present in the gut yet when consumed as drinks both bitter agonists increased vascular tonus in the period immediately after intake. These findings lead to the conclusion that bitter agonists can impact the vasculature via chemosensory reflexes and support the traditional usage of consuming bitter tasting drinks to aid digestion. Subsequently the ingestion of foods and drinks may have a greater impact on the vasculature than hitherto recognised.

Related Topics

    loading  Loading Related Articles