P304The therapeutic potential of the renin-angiotensin-aldosteron system in idiopathic pulmonary arterial hypertension

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Abstract

Rationale: Patients with idiopathic pulmonary arterial hypertension (iPAH) often have a low cardiac output. To compensate, neuro-hormonal systems like renin-angiotensin-aldosteron system (RAAS) and sympathetic nervous system can be upregulated. Although its initial compensatory effects, long-term neuro-hormonal activity can be detrimental.

Objectives

1. Is systemic and local RAAS-activity increased in iPAH-patients?

Objectives

2. Can local RAAS-activity induce pulmonary artery smooth muscle cell (PA-SMC) proliferation?

Objectives

3. Is RAAS-activity a potential therapeutic target for PAH?

Findings

Systemic serum levels of renin, angiotensin I (Ang I) and angiotensin II (Ang II) were increased and associated with disease progression (p < 0.05) and mortality (p < 0.05). RAAS-activity in pulmonary arteries of iPAH-patients was upregulated, characterized by increased ACE-activity in pulmonary endothelial cells.

Findings

Interestingly, Ang II exposure to PA-SMCs of iPAH-patients selectively increased iPAH-PASMC proliferation via enhanced AngII type 1 (AT1) receptor expression and signalling.

Findings

In experimental PAH, chronic RAAS-inhibition with an AT1-receptor antagonist (losartan) delayed pulmonary vascular remodelling, decreased right ventricular afterload and restored right ventricular-arterial coupling.

Conclusions

Systemic and local RAAS-activity is increased in iPAH-patients and associated with increased pulmonary vascular remodelling. The beneficial effects of an AT1-receptor antagonist warrants further clinical investigation and re-evaluation of the use of RAAS-inhibitors for the treatment of iPAH.

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