P309Relationship of neopterin to increased vascular cell adhesion molecule-1 and myeloperoxidase levels in unstable angina

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Abstract

The purpose of the present study was to evaluate serum levels of neopterin, adhesion molecules, and myeloperoxidase (MPO) in coronary artery disease (CAD) patients with stable and unstable angina pectoris (SAP, UAP) and to clarify whether there is a relationship between neopterin and other biomarkers.

Material and Methods

48 patients with CAD were classified into two groups: 24 patients with SA and 24 patients with UAP. 20 healthy subjects were selected as controls (C). Serum soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular cell adhesion molecule-1 (sICAM-1), sE-selectin, and MPO concentrations were determined by Luminex xMAP technology, but serum neopterin concentration was measured by ELISA.

Results

Patients with UAP had significantly higher neopterin, MPO, sVCAM-1, sICAM-1, and sE-selectin levels than healthy control subjects (p < 0.05). The above biomarker, except for sE-selectin, were also elevated in patients with SAP (p < 0.05, but there was no difference between the two patient groups. The only exception was MPO, which was significantly higher in the UAP group (p < 0.05). Neopterin was correlated only with sVCAM-1 (p < 0.05).

Conclusion

The presence of SAP in CAD patients is associated with elevated serum sICAM-1, sVCAM-1, MPO, and neopterin levels. UAP is characterized by more pronounced changes in MPO and there is also a significant increase in serum sE-selectin concentration.

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