P414Dietary magnesium prevents oral contraceptive and fructose impaired glucose tolerance and increased blood viscosity in female rats

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Abstract

Purpose

Prolonged use of oral contraceptive (OC) and increased dietary fructose have been associated with impaired glucose tolerance and increased cardiovascular risk factors while low magnesium intake influences glucose tolerance and haemorheological parameters in oral contraceptive treated and fructose - fed female rats. This aim of the present study was to clarify the effects of variation in dietary magnesium intake on glucose tolerance and blood viscosity, as well as its determinants (haematocrit and plasma viscosity).

Methods

To study this, rats were maintained for 6 weeks on either a control diet, high-fructose with low magnesium diet or a high-fructose with control diet. Some rats received a combined oral contraceptive steroids (ethinyl oestradiol and norgestrel), in addition to either a control or a low- magnesium diet.

Results

Glucose tolerance as area under the curve was significantly reduced in the rats fed on high fructose or treated with OC when maintained on low-magnesium diet when compared with rats maintained on a control diet. Feeding with fructose or OC treatment led to significant increase in haematocrit, plasma viscosity and blood viscosity when rats were maintained on a low-magnesium diet when compared with those maintained on a control diets.

Conclusion

These results show that treatment with OC and feeding on high — fructose diet is associated with impaired glucose tolerance and increased blood viscosity and its determinants. These effects could be prevented by adequate magnesium intake.

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