P424Lipoprotein(a) in undergraduate students

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Abstract

Purpose

The high prevalence of cardiovascular disease (CVD) worldwide can be attributed to genetic predisposition and environmental factors that can lead to the appearance and progression of atherosclerotic plaques. The risk of CVD may be amplified by the presence of factors such as hypertension, smoking, sedentary lifestyle, obesity, stress and dyslipidemia. In this context, lipoprotein(a) [Lp (a)] has been considered an emerging and independent risk factor for CVD. Plasma levels of Lp(a) is fundamental for better understanding of the mechanisms of development of CVD, considering that Lp(a) plasma levels are genetically determined. The present study determined plasma levels of Lp(a) in supposedly healthy individuals, a public university students.

Methods

Plasma levels of Lp(a) were measured in venous blood samples of 68 students, 25 (37%) male and 43 (63%) female, mean age 20.8 ± 1.7 years. Samples were obtained from the student in 12-hour fast, using vacuum tubes without anticoagulant. The determination of Lp(a) was performed using the turbidimetric method. The Mann Whitney and Chi-square test were used for statistical analysis.

Results

The medians and interquartile differences obtained for the participants of the males and females were 9.8 mg/dL (3.1 — 25.7) and 14.7 (6.0 — 40.8), respectively. There was no significant difference between men and women to the plasma levels of Lp(a) (p = 0.098). The most important finding of this study was that 24% of the students had plasma levels of Lp(a) above the reference values, although no significant difference was observed between the percentage of men (20%) and women (28%).

Conclusions

These data indicate that 24% of students assessed, supposedly healthy, have an independent risk factor for CVD. The results lead to actions that will minimize the modifiable factors, especially the sedentary lifestyle, highly prevalent in individuals evaluated.

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