P425Exercise performance, hemodinamic data and heart failure biomarkers in patients with pulmonary arterial hypertension

    loading  Checking for direct PDF access through Ovid

Abstract

Purpose

the evaluation of PAH severity is based on the examination of many parameters simultaneously. The purpose of the study is to find out whether serum NTpro-BNP and uric acid could be the reliable noninvasive parameters for pulmonary arterial hypertension (PAH) severity assessment in patients (pts) with pulmonary arterial hypertension.

Material and methods

26 pts (19F/7M, 43.2 ± 14.3 years):11 idiopathic PAH (IPAH) pts, 5 pts -PAH associated with corrected congenital heart disease (CHD), 8 chronic thromboembolic pulmonary hypertension (CTEPH) pts, 2 pts with scleroderma. 6MWT, right heart catheterization (RHC), serum NTpro-BNP and uric acid concentrations were carried out.

Results

38.5% pts had symptoms of II FC NYHA, 46% pts-class III and 15.5%-class IV. 6MWT was decreased 343.7 ± 136 m. Increased Nt-proBNP and uric acid levels were associated with decreased 6MWT (r=-0.65, p < 0.01; r=- 0.46, p < 0.01 respectively). Negative correlation was determined between uric acid content and oxygen saturation at the end of 6MWT (r=-0.58, p < 0.01). There was negative correlation between NT-proBNP level and systolic arterial pressure (SAP) (r=-0.44, p=0.03), cardiac index (CI) (r=-0.57, p < 0.01), mixed venous oxygen saturation (SvO2) and positive correlation with mean right atrial pressure (RAPm) (r=0.41, p=0.04), pulmonary vascular resistance index (PVRI) (r=0.66, p < 0.01). Positive correlation was revealed between uric acid and RAPm (r=0.48, p=0.03), and negative correlation was observed with CI (r=-0.36, p=0.03) and SvO2 (r=-0.46, p=0.03).

Conclusion

serum NT-proBNP and uric acid are the suitable markers for noninvasive follow-up patients with PAH due to their high correlations with hemodinamic and functional parameters.

Related Topics

    loading  Loading Related Articles