P426Lipid pentad index (LPI), lipid tetrad index (LTI) and atherogenic index of plasma (AIP) in central and peripheral arterial diseases

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Abstract

Purpose

We have previously reported that the apoB/apoA-I ratio was important for identifying an increased trend for coronary and cerebral atherosclerosis. Although lipoprotein(a) [Lp(a)], apolipoprotein A-I (apo A-I) and B (apo B) have been evaluated in several studies involving atherogenic diseases, very few studies have reported the LPI, LTI and AIP, some indexes used to define the overall atherogenic risk. This study investigated the association between atherosclerotic diseases in different anatomical sites and these three atherogenic indexes.

Methods

Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), [Lp(a)], apo A-I and apo B were assessed in 30 subjects with coronary angiographic findings (obstruction >70% - CAD group), 26 ischemic stroke patients (IS), confirmed by magnetic resonance or computer brain tomography, 30 peripheral arterial obstructive disease patients (PAOD), having the ankle/arm index lower than 0.9, and 38 healthy subjects (Controls). LTI [TC × TG × Lp(a)/HDL], LPI [TC × TG × Lp(a) × apo B/apo A-I] and AIP (Log10 TG/HDL) were calculate for all subjects.

Results

No significant differences were observed for TC and LDL among the groups. HDL and apo A-I were significantly lower in PAOD and CAD groups, respectively, than in other groups (p < 0.01). Apo B was significantly higher in IS patients than in control and PAOD groups. The Lp(a) showed significantly higher in CAD and PAOD pacients when compared to control and IS groups. Significantly higher levels of TG, LPI, LTI and AIP were observed for CAD and PAOD patients than for controls. There were also significant differences between PAOD and IS groups for AIP, and between CAD and IS groups for LPI and PTI. Among the three diseases, only CAD was associated with increased Lp(a) levels (r=0.29, p < 0.0001).

Conclusions

The LTI and LPI were important for identifying an increased trend for coronary and peripheral atherosclerosis, in spite of the fact that heterogeneous distribution of lipid and apolipoprotein profiles was observed among the different groups. Additional studies may contribute for a more precise standardization of these indexes as a marker of atherosclerotic risk in different anatomical sites.

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