P521Adiponectin and interleukin-1 receptor antagonist in patients with arterial hypertension

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Abstract

Purpose

Evaluate the relationship between adiponectin and IL-1(ra) in hypertensive patients with different risk of cardiovascular complications.

Methods

The study included 66 male patients with 1 and 2 grade hypertension, aged 35 to 56 years. First group - 17 hypertensive patients with low cardiovascular risk; second group - 20 patients with moderate cardiovascular risk; third group – 29 high risk hypertensive patients. Patients were defined by waist circumference (WC), body mass index (BMI), intima-media thickness(IMT), structural and functional heart condition was assessed using echocardiography. The level of adiponectin in blood serum was measured with Human Adiponectin ELISA kit. IL-1(ra) concentration was evaluated in blood serum with IL-1(ra) ELISA kit.

Results

WC in patients of the first group was 95.3 ± 3.23 cm , BMI - 26.5 ± 1.08 kg/m2, while in the second and third group the figures were significantly higher(WC - 108.33 ± 1.55cm and 106.67 ± 2.67cm respectively, BMI - 31.56 ± 0.53 kg/m2 and 30.52 ± 0.94 kg/m2 respectively). In patients of the first and second groups dyslipidemia was reflected in increased levels of triglycerides and low density lipids. Intima-media thickening ( IMT - 1.44 ± 0.07 mm) and left ventricular hypertrophy (left ventricular mass index - 168.27 ± 7.26 g/m2) occurred in patients of the third group. The level of adiponectin was the highest in the first group - 7.51 ± 1.23 mmol/L. In patients of the second group the concentration of adiponectin did not differ from those of the first group, and in the third group it was 37% lower than in the patients of the first group and was 4.78 ± 0.22 mmol/ L. The changes in IL-1(ra) levels were opposite to the changes of adiponectin. In the first group IL-1(ra) concentration was the lowest -76.60 ± 9.77 pg/mL. Obesity and dyslipidemia were accompanied by a significant overproduction of the cytokine. In comparison with the first group the level of IL-1(ra) in the second group increased by 2.5 times, indicating the presence of inflammatory process in patients with moderate cardiovascular risk without any subclinical organ damage. In patients with organ damage (third group) the level of IL-1(ra) increased by 63% compared with the first group.

Conclusions

Low levels of adiponectin in combination with high concentrations of IL-1 (ra) indicate the activation of inflammatory process in patients with arterial hypertension combined with metabolic syndrome indicators. In hypertensive patients the presence of inflammatory process likely contributes to the initiation of the vascular remodelling processes and the formation of atherosclerotic lesions.

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