Circulation, Vascular biologyP577Spontaneous aggregation and sedimentation of erythrocytes in patients with coronary heart disease: laser measuring system with a probing spatially-modulated beam study

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Abstract

The aim

to study kinetics of spontaneous aggregationand sedimentation of erythrocytes in patients with coronary heart disease.

Materials and methods

78 men with coronary heartdisease (CHD) and 12 practically healthy volunteers were involved in the study.All patients were divided into 3 groups: I - stable angina pectoris (SAP, n=19), II – SAP associated with noninsulin dependent diabetes mellitus (n = 20),III- acute coronary syndrome (n = 39). The application of laser measuringsystem with spatially- modulated probing laser beam for study of properties ofthin and bulk scattering media was considered. Samples of diluted venous bloodwere used as the scattering medium. Time- dependent dynamics of scatteringproperties of blood suspensions was investigated in the course of spontaneoussedimentation and aggregation of erythrocytes.

Results and conclusion

A typical aggregatogram represents6 stages: 1) latent – t1, 2) initial – t2-1, 3)intermediate – t2-2, 4) incisura – t3, 5) transitive(early plateau) stage – t4, and 6) plateau – t5 (Fig.1).Latent stage duration was maximal in group II (7.86 ± 1.73min),and minimal in patients with SAP (2.25 ± 0.56 min). Incisura appearance time was about 17 ± 5 min in all studied groups. t5 wasconsidered as final stage of erythrocytes sedimentation and revealed nosignificant differences in all studied groups. The most interesting parameterwas the amplitude of signal oscillation regarded as erythrocytes aggregatesstability: minimal in practically healthy volunteers and maximal in group III. Received data illustrate erythrocytes functional state violationspotentially responsible for blood flow destabilization and complication ofcoronary heart disease clinical course.

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