P580Immunological changes in collagen metabolism in prehypertensive patients with metabolic syndrome

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Abstract

Metabolic syndrome is associated with early vessel aging, characterized by changes in the vascular wall elasticity. The fibril proteins elastin and collagen occupy an important place in the structure of the vascular wall, and the hemodynamic properties of the vessels are directly dependent on the composition and organization of the extracellular matrix. The aim of the study is to evaluate the immunological parameters of collagen metabolism in subjects with familial predisposition for hypertension with high normal blood pressure and metabolic syndrome. A "case-control" study is conducted on 127 persons, 36 of them are prehypertensive with metabolic syndrome. The methods of the study are based on the enzyme-linked immunosorbent assay for the detection of specific antibodies and the degradation products in the serum, BP measurement, statistical methods.

Results

A weak linear relationship was detected between the pulse pressure / PP / at baseline and IgM-coll-IV-group antibodies in prehypertensive group y = 0.294 x 0.009; r = 0,19; p = 0.02. Between IgG-coll-III and IgM-coll-I-antibodies anticollagenic antibodies a strong correlation was detected - y = 0,220 + 0,522 x; r = 0,90; p = 0,001. Also a strong linear relationship is established between the quantities of IgG-anticollagen-III antibodies and IgM-anticollagen-tipV - antibodies - y = 0,217 + 515 x; r = 0,820; p = 0,002. This relationship demonstrates that IgG - antibodies against collagen type III form in the initial stages of hypertension and there is a relationship between their levels and those against collagen type V. A significant relationship was established between IgA-collagen IV-and IgA-collagen type-I antibodies: y = 0.157 x 0.395; r = 0,525; p = 0,02. Highly correlative relationship was established between the exchange of IgA-coll-IV and IgG-coll-III-antibody y = 0,158 + 0,396 x; r = 0,90; p = 0,0001. Such correlation was also found between IgA-coll-IV and IgM-coll-V-antibody y = 0,145 + 0,41 x; r = 0,9; p = 0,0001. From the investigations carried out, a significant linear relationship was found between the levels of IgG-coll-I-antibodies and IgM-coll-IV-anti-bodies: y = 0,264 + 0,864 x; r = 0,612; p = 0,0007. A significant linear correlation was also found between the levels of IgM-coll-V and IgG-coll-III antibody: y = 0.119 x 1.012; r = 0,693; p = 0,0014.

Conclusions

In prehypertensive patients with metabolic syndrome the collagen turnover of IgG-class type IV collagen is significantly intensified compared to healthy subjects. This occurs even before the blood pressure values reach the levels corresponding to borderline arterial hypertension.

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